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Sources of funding for pharmaceutical research has come under scrutiny in the last decade as academic and government sources of funding have become increasingly scarce and the pharmaceutical industry has become the main source of research dollars. But the issue of objectivity has been raised, and some have even suggested that negative studies, that is studies that show a drug in an unfavorable light, may never be published.
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The ECG in the Figure was interpreted as showing PVCs (premature ventricular contractions) and chamber enlargement. Do you agree? Can you identify at least four findings keyed by the P in this ECG?
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Multivitamin Supplements and HIV Disease Progression and Mortality; The Long-term Outcomes of Sibutramine Effectiveness on Weight (LOSE Weight) Study; Trial of Atorvastatin in Rheumatoid Arthritis (TARA)
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FDA has approved a 5-nitroimidazole for the treatment of trichomoniasis, giardiasis, and amebiasis. Tinidazole, a second-generation nitroimidazole antiprotozoal agent, is marketed as TindamaxTM by Presutti Laboratories.
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Although PPIs are considered to be among the safest of drugs, these studies suggest that PPIs increase the risk for hospitalized patients to develop C. difficile-related diarrhea.
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In a prospective, randomized trial, primary excision of colorectal carcinomas by laparoscopic surgery was compared with laparotomy.
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Herbal medication use is quite common among surgical patients. This pattern is consistent with the recent substantial increase in the use of alternative medical therapies.
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An outbreak of food poisoning by Yersinia pseudotuberculosis in Finland in October/November 1998 involved 46 cases and was traced to locally grown iceberg lettuce.
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Azithromycin therapy failed in a patient in San Francisco with a primary syphilitic chancre which subsequently resolved after administration of a single dose of benzathine penicillin. Sequencing of the 23S rRNA genes of Treponema pallidum from 2 San Francisco patients who had failed azithromycin therapy revealed the presence of a mutation identical to that previously associated with macrolide resistance in a single isolate (T. pallidum, Street 14 strain).
